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SP-40,40 is also called complement lysis inhibitor or clusterin. Clusterin, another soluble complement-regulatory cultured rat glomerular mesangial cells stimulated by sublytic protein, may also play an important role in immune-complement attack. We also demonstrated that in comparison mediated glomerular injury, as perfusion of isolated kid-with control rats, both a marked increase in clusterin mRNA Clusterin has been implicated in a variety of activities including programmed cell death, regulation of complement mediated cell lysis, membrane recycling, cell-cell adhesion, and src induced transformation. As part of the attack complex of complement, it acts as a complement inhibitor.

Clusterin complement

The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. Clusterin antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunohistochemistry (IHC), CoImmunoprecipitation (IP),Enzyme-linked Immunosorbent Assay (ELISA) applications. This antibody reacts with human, mouse, rat samples. Cat.No. 12289-1-AP.

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Clusterin Dimerization of complement factor H-related proteins modulates complement Glial Cell Responses, Complement and Clusterin in the Central Nervous System Following Dorsal Root Transection1998Ingår i: Glia, ISSN 0894-1491, E-ISSN cancer cell origin protects cells against complement attck2005Ingår i: The Prostate, ISSN Serum antibodies against prostasomal clusterin in prostate cancer C1qbp, complement component 1, q subcomponent binding protein, 5526, 292.55 Cluap1, clusterin associated protein 1, 537, 34.67, 42.6, 28.52, 35.26, 5702. 3694 dagar, The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and C1QL1. 10882 complement component 1, q sub. 17.

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Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates. S R Partridge , M S Baker , M J Walker , and M R Wilson Institute for Molecular Recognition, University of Wollongong, New South Wales, Australia. s.partridge@uow.edu.au Clusterin/human complement lysis inhibitor (CLI) is incorporated stoichiometrically into the soluble terminal complement complex and inhibits the cytolytic reaction of purified complement components C5b-9 in vitro. Using an anti-clusterin affinity column, we found that an additional protein componen … Clusterin is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes.

It has a tendency to aggregate cells, including Sertoli cells and erythrocytes. Clusterin has been implicated in a number of biological processes in addition to its role in regulation of complement activation.
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(PICALM) as putative novel 1 Jun 2015 a major amplification step in the early complement activation cascade, whereas clusterin (179), S-protein (180), and CD59 inhibit formation of 15 Aug 2017 The clusterin (CLU) gene is genetically associated with AD and CLU has (1991 ) Clusterin (complement lysis inhibitor) forms a high density 19 Jun 2017 This review will introduce the complement terminal pathway that leads to The plasma factors, vitronectin and clusterin, scavenge dead-end 26 Feb 2019 Complement works with the immune system. Proteins of the complement system react with each other to bind pathogens and trigger an The principal role of clusterin in complement regulation is inhibition of the membrane attack complex by binding C5b-7, preventing the addition of C8 and C9 The complement cascade enhances (i.e. complements) the ability of antibodies and phagocytic cells (a type of white blood cells) to clear microbes and damaged 22 Nov 2012 http://armandoh.org/Overview of the Complement System and the pathways involved and their relationship with each other.Image: In November 2015, Dr. Jamile Shammo of Rush University Medical Center spoke about hemolysis (destruction of red blood cells) in PNH. In this interview she A novel mutation in the complement regulator clusterin in recurrent haemolytic uraemic syndrome. / Ståhl, Anne-lie; Kristoffersson, Ann-Charlotte; Roodhooft, Status, Published - 2008. Publikationskategori, Forskning.

Clusterin is a component of glomerular immune deposits in the kidney, and increased Clusterin expression occurs in a number of renal injury states. Clusterin protein colocalized with the membrane attack complex of complement and vitronectin in the center of the largest Hassal's bodies, but was not detectable by immunocytochemistry in or at the surface of epithelial cells. Clusterin is a heterodimeric glycoprotein that has been associated with such diverse biologic functions as reproduction, cell regression, cell aggregation, and regulation of the cytolytic activity of the membrane attack complex of complement. Clusterin is a component of glomerular immune deposits in the kidney, and increased Clusterin expression occurs in a number of renal injury states.
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We examined the relationship between clusterin and activated complement in human heart infarction and evaluated the effect of this protein on ischemic rat neonatal cardiomyoblasts (H9c2) and isolated adult ventricular rat cardiomyocytes as in vitro models of acute myocardial infarction. complement activation Source: ProtInc "Clusterin: the intriguing guises of a widely expressed glycoprotein." Jenne D.E. , Tschopp J. Trends Biochem Sci 17:154-159(1992) [ PubMed ] [ Europe PMC ] [ Abstract ] Two genome-wide association studies (GWAS) have identified apolipoprotein E, (APOE) clusterin (CLU), complement receptor 1 (CR1) and the phosphatidylinositol binding clathrin assembly protein, PICALM, as major susceptibility genes in Alzheimer's disease. Conclusions —Shear stress abrogates the complement-induced proinflammatory response of ECs by upregulation of the complement-inhibitory protein clusterin. Upregulation of clusterin may contribute to the potent antiatherosclerotic effects of shear stress by preventing endothelial activation through the complement cascade. Dog Clusterin (CLU) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Clusterin (CLU) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.